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Scientific committee
Paolo Bernardi, Alessandro Giuffrè, Giovanna Lippe, Vito De Pinto, Francesco Francia, Cesare Indiveri, Luigi Palmieri, Claudia Piccoli.
Organizing committee
Vito De Pinto, Angela Messina, Francesca Guarino, Flora Tomasello, Simona Reina, Andrea Magrì, Loredana Leggio, Maria Carmela Di Rosa, Marinella Pittalà.
Secretariat
Vito De Pinto, Francesca Guarino, Angela Messina Tel. +39 095 738 4244 - 4231 Email: catania2017@gibb-be.org; vdpbiofa@unict.it; fguarin@unict.it; mess@unict.it
Registration Deadline
10th May, 2017. On-line registration at www.gibb-be.org
Registration fee
120.00 Euro (early registration, before May 10th); 200.00 Euro (delayed registration, until May 30th). Social dinner and lunch meals are included.
Venue
Aula Magna - Monastero dei Benedettini – Piazza Dante, 32 – Catania
37°30′14.75″N 15°04′18.1″E
Transportation
Catania can be reached by car, train, ship and airplane. The easiest way is by airplane: Fontanarossa airport is well connectd with many european and domestic flights. A dedicated bus (Alibus) connects the airstation to the main spots downtown.
In the city there are bus services (http://www.amt.ct.it) and an underground line (http://www.circumetnea.it).
Accommodation
Recommended Hotels and B&B close to the meeting venue (see the map) are marked with Green Beds (the red arrow indicates the meeting venue):
Il Principe Hotel (4****); Hotel Mercure Catania Excelsior (4****);
Plaza Hotel (4****);
Hotel NH Catania centro (4****);
Katane Palace Hotel (4****);
Royal Hotel (4 ****);
Una Palace Hotel (4****);
Best Western Hotel Mediterraneo (3***);
Hotel Etnea 316 (3***);
Manganelli Palace (3***);
San Max Hotel (3***);
Hotel Agathae (3***); BAD Bed&Breakfast and Design; B&B Etnea 55; B&B Palazzo Bruca; Stesicoro B&B Catania.
At NH Catania centro (4****) (nhcataniacentro@nh-hotels.com) some rooms are pre-booked for GIBB meeting participants until 14.04.2017.
Recommended Bed&Breakfasts of the HELPBnB circuit can be booked using the website http://www.helpbnb.com and will reserve a 10% discounted room rates for GIBB meeting participants (coupon code: gibbint2017). The B&B partners of the meeting are marked with Blue pointers in the map.
Bellini Home B&B;
Acquadellarte B&B;
Catania Bedda B&B;
EH13 B&B;
B&B Fera O’Luni;
Inn the Garden;
B&B Miro;
Ottomood Catania Centro;
Papali B&B;
Casa Barbero Charme&Rooms.
IMPORTANT: do not delay the booking of your accommodation, because in June Catania will be in the tourist season and there will also be other meetings.
Oral presentations and abstract submission Deadline
10th May 2017.
The abstracts, not exceeding one A4 page and with the presenting author name underlined, should be submitted on-line at www.gibb-be.org. Please utilize the abstract form present in the web site.
Oral presentations usually last 10 min + 5 min discussion (final info will be provided when all abstracts are received). English will be the official language at the meeting.
Program
Wednesday 14th
13:00 Registration
15:00 Welcome Address
Authorities, GIBB President and the Organizing Committee
15:30 Opening Plenary Lecture
Chair: Paolo Bernardi (University of Padua, Italy)
Sir John Walker, Nobel laureate (University of Cambridge, United Kingdom)
"The respiratory chain in mitochondria: a triumph for biochemistry and biophysics"
16:45 Session I: ATPsynthase and the complexes of respiratory chain
Oral Presentations
Chair: Giovanna Lippe (University of Udine, Italy),
Nazareno Capitanio (University of Foggia)
16:45 Clara Ferreira Pereira (University of Porto, Portugal)
Phosphoproteomic screening identifies ATP synthase beta subunit as a target of the
yeast type 2A-like protein phosphatase Sit4p
17:00 Danilo Faccenda (Royal Veterinary College, London, United Kingdom)
Control of mitochondrial bioenergetics and structure by the ATPase inhibitory factor 1:
a pro-survival relay via OPA1
17:15 Andrea Urbani (University of Padua, Italy)
Electrophysiological properties of channel formed by bovine FOF1 ATP synthase in
planar lipid bilayer
17:30 Lishu Guo (University of Padua and CNR Institute of Neuroscience, Italy)
Matrix Ca2+ is essential for opening of the mitochondrial permeability transition pore
17:45 Marco Malferrari (University of Bologna, Italy)
The cytochrome b H291L mutation strongly impairs ubiquinol oxidation and proton
translocation at the bacterial bc1 QO site
18:00 Karen Trchounian (Yerevan State University, Armenia)
Input of hydrogenases in H2 cycling and proton motive force generation in Escherichia
coli during fermentation
18:15 End of Session
18:30 Welcome cocktail
Giardino dei Novizi
20:00 Guided tour of Monastero dei Benedettini
Thursday 15th
9:15 Plenary lecture
Chair: Vito De Pinto (University of Catania, Italy)
Karin B. Busch (Westfalische Wilhelms-University of Munster, Germany) "Structural and functional OxPhos micro-compartments recorded in live cells"
10:00 Session II: Specialized transporters and pores, structure & function
Oral presentations
Chair: Cesare Indiveri (University of Calabria, Italy)
10:00 Vanessa Checchetto (University of Padua, Italy)
A new mitochondrial potassium channel involved in cardioprotection
10:15 Simona Reina (University of Catania, Italy)
VDAC3 cysteine oxidation state and channel activity: in vitro and in cellulo studies
10:30 Mariafrancesca Scalise (University of Calabria, Italy)
Structure/function relationships of human LAT1 amino acids transporter and screening of active-site targeted inhibitors
10:45 Lara Console (University of Calabria, Italy)
Regulation of the mitochondrial carnitine/acylcarnitine carrier by S-nitrosylation
11:00 Maria Carmela Di Rosa (University of Catania, Italy)
The second VDAC isoform in S.cerevisiae, an unknown protein: structural-functional characterization
11:15 Coffee break
Chiostro di Levante
12:00 Session III: Specialized transporters and pores, physiological and pathological roles
Oral presentations
Chair: Francesco Francia (University of Bologna)
12:00 Luigi Leanza (University of Padua, Italy)
Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo
12:15 Daria Grobys (Adam Mickiewicz University in Poznan, Poland)
VDAC in viability and energetic coupling status of the inducible PC12 cell model of Huntington's disease
12:30 Daria Grobys (Adam Mickiewicz University in Poznan, Poland)
VDAC in viability and energetic coupling status of the inducible PC12 cell model of Huntington's disease
12:45 Roberta Peruzzo (University of Padua, Italy)
Novel psoralen-derivatives with increased solubility in cancer treatment
13:00 BMR GENOMICS: Sponsor Talk
13:30 Lunch
Chiostro di Levante
15:00 Plenary lecture
Chair: Alessandro Giuffre (University of Rome La Sapienza, Italy)
Dr. Christian Frezza (University of Cambridge, United Kingdom) "Mitochondrial dysfunction and cancer: beyond metabolism"
15:45 Session IV: Bioenergetics metabolism and mitochondrial dysfunction
Oral presentations
Chair: Giancarlo Solaini (University of Bologna, Italy)
15:45 Ferdinando Chiaradonna (University of Milano-Bicocca, Italy)
Protein kinase A activation promotes cancer cell resistance to glucose starvation and
Anoikis
16:00 Lara Gibellini (University of Modena and Reggio Emilia, Italy)
LonP1 differently modulates mitochondrial function and bioenergetics of primary
versus metastatic colon cancer cells
16:15 Giacomo Lazzarino (Catholic University of Rome, Italy)
The response of the mitochondrial quality control system to graded traumatic brain
Injury
16:30 Francesca Malagrino (CNR Institute of Molecular Biology and Pathology, Rome, Italy)
Novel pathogenic mechanisms from investigation of human hydrogen sulphide metabolism
16:45 Marco Schiavone (University of Padua and CNR Institute of Neuroscience, Italy)
Alisporivir rescues mitochondrial respiratory dysfunction in Duchenne muscular dystrophy models
17:00 Coffee break
Chiostro di Levante
17:30 Session V: Reactive Oxygen Species and mitochondria
Oral presentations
Chair: Claudia Piccoli (University of Foggia, Italy)
17:30 Ginevra Nannelli (University of Siena, Italy)
The role of mitochondria in the maintenance of endothelial function after exposure to redox injury
17:45 Giulia Gorini (University of Bologna, Italy)
Reactive oxygen species decrease in human cells adapted to hypoxia
18:00 Marianna Tomasello (CNR Institute of Biostructures and Bioimaging, Catania, Italy)
Misfolded SOD1 mutant alters VDAC1-Hexokinase 1 complexes promoting mitochondrial dysfunction in an Amyotrophic Lateral Sclerosis model
18:15 Andrea Magrì (University of Catania, Italy)
Hexokinases 1 peptide protects VDAC1 from SOD1 G93A mutant toxic interaction in an ALS model: implications for the neurodegenerative disease’s treatment
18:30 Gloria Scattolin (University of Padua, Italy)
Mitochondrial reactive oxygen species sensitize T-ALL cells to apoptosis by engaging the OMA1-OPA1 axis
18:45 GIBB Members Annual Meeting
20:00 Bus Meeting Point at piazza Dante (in front of Monastero)
20:30 Social Dinner
Ristorante Feudo Delizia, Mount Etna
Friday 16th
9:15 Plenary lecture
Chair: Angela Messina (University of Catania, Italy)
Prof. Laszlo Tretter (Semmelweis University , Budapest, Hungary) "
Cyclophylin D KO protects against bioenergetic changes detected in Alzheimer's model (Tg(APPSwe)/Tg(PSEN1)) mice"
10:00 Session VI: New and notable themes in Bioenergetics and Biomembranes
Oral presentations
Chair: Marcello Pinti (University of Modena & Reggio Emilia, Italy),
Alexander Ruban (University of London, United Kingdom)
10:00 Alexander Ruban (University of London, United Kingdom)
Dynamic photosynthetic membrane
10:15 Kylie A. Minor (University of Alberta, Canada)
Light-Driven Energy Production for Cell-Free Metabolic Systems
10:30 Wolfgang Buckel (Philipps University of Marburg, Germany)
Flavin-based electron bifurcation in anaerobic Bacteria and Archaea
10:45 Nunzio Iraci (University of Catania, Italy and of Cambridge, United Kingdom)
Extracellular vesicles are independent metabolic units with asparaginase activity
11:00 Andonis Karachitos (Adam Mickiewicz University in Poznan, Poland)
Mitochondria monitoring in studies of successful anhydrobiosis
11:15 Coffee break
Chiostro di Levante
11:45 Mary F. Rooney (Trinity College Dublin, Ireland)
Genotype variation at the MSTN locus is associated with skeletal muscle mitochondrial
abundance and fibre composition in untrained Thoroughbred horses
12:00 Claudio Laquatra (University of Padua, Italy)
Zebrafish (Danio rerio) as a model to study the pathophysiological role of the
mitochondrial chaperone TRAP1
12:15 Sarfarazhussain Farooqui (University of Vienna, Austria)
Analysis of the role of Letm1 in the development of zebrafish
12:30 Martina La Spina (University of Padua and CNR Institute of Neuroscience, Italy)
Induction of autophagy and mitochondrial biogenesis by the natural compound
Pterostilbene: mechanisms and biomedical potential
12:45 Antonio Filippi (University of Udine, Italy)
Flavonoid transport in plant microsomes: characterization of quercetin uptake
13:00 Concluding remarks and awards
13:30 LunchBox
Chiostro di Levante
14:30 End of the meeting