Riunione Annuale 2015 - Udine

Programme

Thursday 18th June

14:00-15:00 Registration
15:00-15:15 Welcoming address
15:15-15:30 Opening
Giancarlo Solaini (GIBB President), Giovanna Lippe

15:30-16:30 Opening Lecture
MITOCHONDRIA AND CALCIUM SIGNALING IN ENERGY HOMEOSTASIS AND CELL DEATH
Michael Duchen (University College London, U.K.)

16:30-18:45 CALCIUM SIGNALING & MITOCHONDRIA STRUCTURE
Chairpersons: Giancarlo Solaini – Alessandro Giuffrè
16:30-16:45 Ca2+ BINDING TO THE CATALYTIC Me2+ BINDING SITE OF F-ATP SYNTHASE
PROMOTES FORMATION OF THE PERMEABILITY TRANSITION PORE
Valentina Giorgio, Victoria Burchell, Marco Schiavone, Michael Forte, Valeria Petronilli, Giovanna Lippe and Paolo Bernardi
16:45-17:00 MODULATION OF F-ATP SYNTHASE/PTP BY pH
Manuela Antoniel, Barbara Spolaore,Valentina Giorgio, Federico Fogolari,Valeria Petronilli, Paolo Bernardi and Giovanna Lippe
17:00-17:15 MODULATION OF THE F1FO-ATPASE AND MITOCHONDRIAL PERMEABILITY TRANSITION PORE ACTIVITY BY THE MITOCHONDRIAL PROTEASE HTRA2
Victoria S. Burchell, Hélène Plun-Favreau and Paolo Bernardi
17:15-17:30 DISCOVERY AND OPTIMIZATION OF NOVEL INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE
Justina Šileikytė, Paolo Bernardi and Michael Forte
17:30-17:45 HUMAN ND1 SUBUNIT IS ESSENTIAL FOR COMPLEX III AND SUPERCOMPLEXES STABILITY
Luisa Iommarini, Maria Antonietta Calvaruso, Concetta Valentina Tropeano, Anna Ghelli, Ivana Kurelac, Giulia Leone, Renaud Vatrinet, Sara Vidoni, Massimo Zeviani, Anne Lombes, Michela Rugolo, Giuseppe Gasparre and Anna Maria Porcelli
17:45-18:00 OPA1 ISOFORMS AND PROTEIN DOMAINS IN THE MITOCHONDRIAL FUNCTIONS
Valentina Del Dotto, Prashant Mishra, Sara Vidoni, Mario Fogazza, Guy Lenaers, Valerio Carelli, David Chan, Michela Rugolo and Claudia Zanna
18:00-18:15 MITOCHONDRIAL TRANSLOCATION OF APE1 RELIES ON THE MIA PATHWAY
Arianna Barchiesi, Michal Wasilewski, Agnieszka Chacinska, Gianluca Tell and Carlo Vascotto
18:15-18:45 CAREER DEVELOPMENT BY BRIDGING RESEARCH WITH SOCIETY: THE EXPERIENCE AND THE RESULTS OF TRANS2CARE PROJECT.
Sabina Passamonti

19:00 Get together party

Friday 19th June

8:30- 9:30 Plenary lecture
MITOCHONDRIA AND HYDROGEN SULFIDE
Frederich Bouilaud (University of Paris Descartes, France)

9:30-10:45 MITOCHONDRIA DYSFUNCTION I
Chairpersons: Luigi Palmieri - Michela Rugolo
9:30-9:45 THE MITOCHONDRIAL CARNITINE/ACYLCARNITINE CARRIER IS REGULATED BY HYDROGEN SULFIDE VIA INTERACTION WITH C136 AND C155
Lara Console, Nicola Giangregorio, Annamaria Tonazzi, Imma Lorusso, Annalisa De Palma, Cesare Indiveri
9:45-10:00 PEROXYNITRITE DECOMPOSITION BY E. coli CYTOCHROME BD OXIDASE
Elena Forte, Vitaliy B. Borisov, Micol Falabella, Sergey A. Siletsky, Marzia Arese, Albert Davletshin, Daniela Mastronicola, Paolo Sarti and Alessandro Giuffrè
10:00-10:15 NITRIC OXIDE: A ROLE IN LEBER’S HEREDITARY OPTIC NEUROPATHY
Micol Falabella, Elena Forte, Kristina Radić, Maria Chiara Magnifico, Marzia Arese, Alessandro Giuffrè, Marco Salvetti and Paolo Sarti
10:15-10:30 ACTIVATION OF COMPLEX II BY HYDROGEN PEROXIDE IN COMPLEX III DEFICIENT CELLS
Concetta Valentina Tropeano, Leonardo Caporali, Valerio Carelli, Michela Rugolo and Anna Maria Ghelli
10:30-10:45 DO REACTIVE OXYGEN SPECIES INCREASE OR DECREASE IN HUMAN FIBROBLASTS ADAPTED TO HYPOXIA?
Giulia Gorini, Gianluca Sgarbi, Simona Barbato, Alessandra Baracca and Giancarlo Solaini

10:45-11:15 Coffee break

11:15-13:00 MITOCHONDRIA DYSFUNCTION II
Chairpersons: Marcello Pinti – Anna Maria Tonazzi
11:15-11:30 IMPAIRMENT OF MUSCLE OXIDATIVE FUNCTION IN VIVO FOLLOWING MUSCLE DISUSE: WHAT IS THE ROLE OF MITOCHONDRIA?
Desy Salvadego, Michail E. Keramidas, Jörn Rittweger, Irene Mavelli, Ola Eiken, Igor B. Mekjavic and Bruno Grassi
11:30-11:45 SUCCESSFUL TREATMENT WITH INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE IN A ZEBRAFISH MODEL OF COLLAGEN VI MUSCULAR DYSTROPHY
Marco Schiavone, Justina Šileikytė, Alessandra Zulian, Erika Rizzo, Francesca Tagliavini, Luciano Merlini, Patrizia Sabatelli, Sudeshna Roy, Frank Schoenen, Michael Forte, Francesco Argenton and Paolo Bernardi
11:45-12:00 TARGETING MITOCHONDRIAL METABOLISM TO MODULATE THE MACROPHAGE IMMUNE RESPONSE: A PRELIMINARY STUDY WITH PARA-HYDROXYPHENYLPYRUVATE
Rosella Scrima, Marta Menga, Simona Siliberti, Alessandra De Gregorio, Giuliana Villani, Antonella Cotoia, Julia V. Gefter, Gilda Cinnella and Nazzareno Capitanio
12:00-12:15 ATPase-INHIBITORY FACTOR 1 AND OXPHOS COMPLEXES IN HUMAN GLIOMAS
Alessia Buso, Marina Comelli, Veronica Candotti, Daniela Cesselli and Irene Mavelli
12:15-12:30 INHIBITION OF LON PROTEASE BY TRITERPENOIDS CDDO AND CDDO-ME ALTERS MITOCHONDRIA AND CAUSES CELL DEATH IN RKO HUMAN COLON CANCER CELLS
Regina Bartolomeo, Lara Gibellini, Simone Pecorini, Elena Bianchini, Sara De Biasi, Antonella Cormio, Andrea Cossarizza and Marcello Pinti
12:30-12:45 TARGETING MITOCHONDRIAL COMPLEX I TO INDUCE PSEUDONORMOXIA: AN ADJUVANT ANTI-CANCER STRATEGY
Ivana Kurelac, L. Iommarini, R. Vatrinet, L. Amato, C. Calabrese, L. Giulia, G. Girolimetti, M. Vidone, M. De Luise, C. Bergamini, F. Marzano,MF. Caratozzolo, M. Columbaro, R. Fato, M. Rugolo, A. Tullo, G. Gasparre and A.M. Porcelli
12:45-13:00 CALPAINS, CASPASES, HEAT SHOCK PROTEINS AND TENDERNESS OF BEEF
Elena Saccà, Mirco Corazzin, Nicoletta Pizzutti, Giovanna Lippe and Edi Piasentier

13:00-14:30 Lunch

14:30-15:30 Plenary lecture
GLUTAMINE MEMBRANE TRANSPORT: FROM ENERGY SUPPLY TO NUTRIENT SENSING
Cesare Indiveri (University of Calabria)

15:30-16:30 Membrane transporters: structure & function I
Chairpersons: Mario Zoratti – Francesco Francia
15:30-15:45 STRATEGIES FOR BACTERIAL EXPRESSION AND LARGE SCALE PURIFICATION OF HUMAN AMINO ACID TRANSPORTERS
Michele Galluccio, Lorena Pochini, Mariafrancesca Scalise, Manuele Rebsamen, Giulio Superti Furga and Cesare Indiveri
15:45-16:00 SLC7A5 (LAT1) PLAYS THE ROLE OF CATALYZING AMINO ACID TRANSPORT IN THE LAT1/CD98 HETERODIMER.
Lara Napolitano, Mariafrancesca Scalise, Michele Galluccio, Lorena Pochini, Leticia Albanese and Cesare Indiveri
16:00-16:15 IDENTIFICATION OF NEW HIGHLY SELECTIVE INHIBITORS OF THE HUMAN ADP/ATP CARRIERS.
Giandomenico Redavid, Angelo Onofrio, Simona Todisco, Maria Antonietta DiNoia, Giovanni Parisi, Giuseppe Punzi, Anna De Grassin and Ciro Leonardo Pierri
16:15-16:30 ALS-LINKED MUTANT SOD1 G93A INTERACTING WITH VDAC1 CHANNEL AFFECTS ITS VOLTAGE-GATING ACTIVITY
Ramona Belfiore, Andrea Magrì, Simona Reina, Vito De Pinto and Angela Messina

16:30-17:00 Coffee break

17:00-18:00 Membrane transporters: structure & function II
Chairpersons: Nazzareno Capitanio – Giovanna Lippe
17:00-17:15 TRANSFORMATION WITH hSOD1 OF S. cerevisiae DEVOID OF ENDOGENOUS VDAC1 IMPROVES THE DEFECTIVE PHENOTIPE AND RE-ESTABLISH THE MITOCHONDRIAL METABOLISM
Maria Carmela Di Rosa, Francesca Guarino, Andrea Magrì, Simona Reina, Flora Tomasello, Angela Messina and Vito De Pinto
17:15-17:30 ALTERNATIVE 5’-UTR SEQUENCES OF VDAC GENE IN Drosophila melanogaster REGULATE THE TRANSLATION OF DOWNWARD CODING SEQUENCE
Loredana Leggio, Massimo Tommasino, Vito De Pinto and Angela Messina
17:30-17:45 IN VIVO ASSAY TO MONITOR FLAVONOID UPTAKE ACROSS PLANT CELL MEMBRANES
Antonio Filippi, Elisa Petrussa, Carlo Peresson, Alberto Bertolini, Angelo Vianello and Enrico Braidot
17:45-18:00 MITOCHONDRIAL TRANSPORT OF ADMA BY SLC25A2
Vito Porcelli, Antonella Longo, Luigi Palmieri, Ellen Closs and Ferdinando Palmieri

18:00-19:00 GIBB member assembly

20:30 Social dinner (Ristorante “Concordia”, p.zza I maggio)

Saturday 20th June

9:00- 10:00 Plenary lecture
DISSECTING MITOCHONDRIAL ENERGY PHYSIOLOGY AND REGULATION BY IN VIVO IMAGING IN PLANTS
Markus Schwarzländer (University of Bonn, Germany)

10:00-10:30 BIOENERGETIC IN PHOTOSYNTHETIC ORGANISMS I
Chairpersons: Vito De Pinto – Marco Zancani
10:00-10:15 ATP SYNTHASE DIMERS FROM PEA STEM MITOCHONDRIA FORM THE PTP
Valentina De Col, Carlo Peresson, Elisa Petrussa, Valentino Casolo, Sonia Patui, Alberto Bertolini, Valentina Giorgio, Vanessa Checchetto, Enrico Braidot, Giovanna Lippe, Ildiko Szabò, Angelo Vanello, Paolo Bernardi and Marco Zancani
10:15-10:30 ALTERNATIVE SPLICING-MEDIATED TARGETING OF THE ARABIDOPSIS GLUTAMATE RECEPTOR 3.5 TO MITOCHONDRIA AFFECTS ORGANELLE MORPHOLOGY
Enrico Teardo, Luca Carraretto, Sara De Bortoli, Alex Costa, Smrutisanjita Behera, Richard Wagner, Fiorella Lo Schiavo, Elide Formentin and Ildiko Szabò

10:30-11:00 Coffee break

11:00-12:00 BIOENERGETIC IN PHOTOSYNTHETIC ORGANISMS II
11:00-11:15 MUTATION OF CYTOCHROME B H291 IMPAIRS UBIQUINOL OXIDATION AT THE QO SITE OF THE BACTERIAL CYTOCHOME BC1 COMPLEX
Marco Malferrari, Fevzi Daldal, Giovanni Venturoli and Francesco Francia
11:15-11:30 UNCOVERING THE REDOX REGULATION AND THE STRUCTURAL FEATURES OF TRANSKETOLASE FROM Chlamydomonas reinhardtii
Miriam Pasquini, Chiara Sciabolini, Simona Fermani, Laure Michelet, Stéphane D. Lemaire, Francesco Francia and Mirko Zaffagnini
11:30-11:45 ZmDUR3, CHARACTERIZATION OF A HIGH AFFINITY UREA TRANSPORTER IN MAIZE ROOTS
Laura Zanin, Nicola Tomasi, Corina Wirdnam, Stefan Meier, Doris Rentsch and Roberto Pinton
11:45-12:00 CHARACTERIZATION OF A GENISTEIN TRANSPORTER IN CLUSTER ROOTS OF WHITE LUPIN
Silvia Venuti, Laura Zanin, Enrico Martinoia, Roberto Pinton and Nicola Tomasi

12:15-13:00 Awards and closing remarks