PROGRAM
THURSDAY, 15TH JUNE 2006
13.00 – 15.00 Registration
15.00 Opening addresses
MOLECULAR STRUCTURES OF MEMBRANE PROTEIN COMPLEXES
Chairman: Sergio Papa (University of Bari)
15.10 Structural complexity of neuronal nicotinic receptors.
Francesco Clementi (University of Milano)
15.50 Oligomeric states of F0F1ATP-synthase in bovine heart mitochondria.
E. Bisetto, F. Di Pancrazio, V. Alverdi, I. Mavelli, G. Lippe (University of Udine)
16.10 Oligomeric properties of the ATP synthase inhibitory peptide IF1 from Saccharomyces cerevisiae.
E. Bisetto, V. Corves, C. Sigalat, G. Lippe, F. Haraux (University of Udine)
16.30 Effect of ADP and Pi on the intrinsic uncoupling in the ATP synthase of E.coli.
M. D’Alessandro, P. Turina and B. A. Melandri (University of Bologna)
16.50 Can the proton pumping efficiency of ATP synthase be regulated?
A. Rebecchi, P. Turina, B. A. Melandri (University of Bologna)
17.10 – 17.30 COFFEE BREAK
Chairman: Paolo Sarti (University of Rome)
17.30 Stabilization of the charge separated state and distribution of the ubiquinone pool in reaction center-light harvesting complexes purified from Rhodobacter shaeroides.
M. Dezi, F. Francia, G. Palazzo, A. Maliardi, G. Venturoli (University of Bologna)
17.50 X-ray absorption studies of Zn2+ binding sites in bacterial, avian and bovine cytochrome bc1 complexes.
L. Giachini, F. Francia, D-W. Lee, F. Daldal, L-S. Huang, E.A. Berry, T. Cocco, S. Papa, F. Boscherini , G. Venturoli (University of Bologna)
18.10 The Cub-lacking cytochrome BD oxidase and nitric oxide.
E. Forte, V.B. Borisov, A. Giuffrè, M. Brunori, F. M. Scandurra, A.A. Konstantinov, P. Sarti (University of Rome “La Sapienza”)
18.30 The flux control of cytochrome c oxidase on cell respiration is controlled by mitochondrial membrane potential and mediated by cardiolipin.
G. Quarato, C. Piccoli, R. Scrima, D. Boffoli, N. Capitanio (University of Foggia)
20.30 DINNER
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FRIDAY, 16th JUNE 2006
NITRIC OXIDE AND ROS BIOLOGY
Chairman: Giorgio Lenaz (University of Bologna)
9.00 Role of nitric oxide in mitochondrial function and biogenesis.
Emilio Clementi (Univ. di Milano )
9.40 The role of flavodiiron proteins in nitric oxide detoxification
J. B. Vicente, M. C. Justino, L.M. Saraiva, M.Teixeira, F. M. Scandurra, E.Forte, M. Brunori , P. Sarti, A. Giuffrè (University of Rome “La Sapienza”)
10.00 Correlative analysis between hematopoietic stem cells differentiation and mitochondriogenesis.
A. D’Aprile, C. Piccoli, R. Scrima, L. Lecce, D. Boffoli, A. Tabilio, N. Capitanio (University of Foggia)
10.20 Melatonin protects against mitochondrial dysfunction associated with cardiac ischemia-reperfusion by preventing ROS-induced cardiolipin oxidation.
G. Petrosillo, N. Di Venosa, M. Pistolese, G. Casanova, E. Tiravanti, G. Colantuono, A. Federici, F.M. Ruggiero, G. Paradies (University of Bari)
10.40 – 11.10 COFFEE BREAK
Chairman: Giuseppe Paradies (University of Bari)
11.10 Exploiting the effect of complex I inhibitors and the role of endogenous/ exogenous quinones on ROS production and on NADH-DCIP reductase activity.
R. Fato, C. Bergamini, S. Leoni, G. Lenaz (University of Bologna)
11.30 Succinate control of H202 generation in mitochondria.
F. Zoccarato, L. Cavallini, S. Bortolami, E. Comellato and A. Alexandre (University of Padova)
11.50 Effects of inhibitors of NAD(P)H oxidase on glucose transport activity in a leukaemic cell line.
C. Prata, T. Maraldi, D. Fiorentini, L. Zambonin, G. Hakim, L. Landi (University of Bologna)
12.10 Mitochondrial oxidative metabolism in interleukin 7-engineered stromal cells.
R. Scrima, C. Piccoli, M. Ripoli, A. D’Aprile, D. Boffoli, A. Tabilio, S. Papa,
N. Capitanio (University of Foggia)
12.30 The differentiation process of human monocyte-derived dendritic cells: possible role of mitochondria and reactive oxygen species.
M.Di Paola, C.Oliveros Celis, A.Del Prete, P.Zaccagnino, G.Santoro, M.Lorusso
(University of Bari)
13:00 LUNCH
MITOCHONDRIAL DYSFUNCTIONS
Chairman: Luca Scorrano (Dulbecco-Telethon Institute, VIMM, Padova)
15.00 Paraplegin-AFG3L2 complex, a large mitochondrial metalloprotease with a role in neurodegeneration and not only
Giorgio Casari (San Raffaele, Milano)
15.40 Generation of a transgenic mouse model overexpressing OPA1, a mitochondria-shaping protein mutated in dominant optic atrophy.
V. Costa, S. Cipolat, L. Scorrano (Dulbecco-Telethon Institute, VIMM, Padova)
16.00 OPA1 controls apoptotic cristae remodelling independently from mitochondrial fusion.
C.Frezza, S. Cipolat, O. Martins de Brito, M. Micaroni, G.V. Beznoussenko, T. Rudka, D. Bartoli, R.S. Polishuck, N.N. Danial, B. De Strooper, L.Scorrano (Dulbecco-Telethon Institute, VIMM, Padova)
16.20 Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1 dependent cristae remodeling.
S. Cipolat, T. Rudka, D. Hartmann, V. Costa, L. Serneels, K. Craessaerts, K. Metzger, C. Frezza, W. Annaert, L. D’Adamio, C. Derks, T.Dejaegere, L. Pellegrini, R. D’Hooge , L. Scorrano, B. De Strooper (Dulbecco-Telethon Institute, VIMM, Padova)
16.40 Energetic efficiency and mitochondrial fusion in fibroblasts from Dominant Optic Atrophy patients bearing the C.2708delTTAG OPA1 mutation.
C. Zanna, A. Ghelli, A. M. Porcelli, M. Karbowski, R.J. Youle, V.Carelli, M.Rugolo (University of Bologna
17.00 – 17.20 COFFEE BREAK
Chairman: Giancarlo Solaini (University of Bologna)
17.20 Functional and molecular responses to stress conditions in heteroplasmic MELAS 3243 RD cybrids.
L. Vergani, E. Loro, A. Malena, S. Cazzorla, A. Marchetto (University of Padova)
17.40 Comparative bioenergetic studies of cells carrying the 8993T>G or 8993T>C mitochondrial DNA mutations.
G. Sgarbi, A. Baracca, M.Mattiazzi, V. Carelli, G. Lenaz, G.Solaini (University of Bologna)
18.00 New insights in the pathophysiology of riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency (RR-MAD).
C.Brizio, E. Gianazza, A. Russell, R. Wait, C. Angelini, F. Dabbeni-Sala, D. Bufano, I. Eberini, B. Lenger, M. Barile, L. Vergani (University of Padova
18.20 Megacarioblastic leukemia and mitochondria: a case report.
M. Ripoli, C. Piccoli, R. Scrima, O. Cela, D. Boffoli, A. Tabilio, M. Carella, N. Capitanio (University of Foggia)
19.00 MEETING FOR GIBB MEMBERS
20:30 SOCIAL DINNER
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SATURDAY, 17th JUNE 2006
MEMBRANES AND TRANSPORT
Chairman: Cesare Indiveri (University of Arcavacata di Rende )
9.00 Regulated Exo-Endocytosis, an expanding world: properties and role of a new - exocytic organelle, the enlargeosome.
Jacopo Meldolesi (Università Vita-Salute, Milano)
9.40 Functional and structural characterization of the N-terminal peptide of the mitochondrial VDAC1.
V. De Pinto, A. Messina, R. Aiello, F. Tomasello, D. La Mendola, A., Magrì, D. Milardi, G. Pappalardo (University of Catania)
10.00 Dynamic aspects of the mitochondrial carnitine/acylcarnitine carrier structure, as revealed by chemical modification of four replacement cys mutants.
C. Indiveri, A.Tonazzi, N. Giangregorio, F. Palmieri (University of Arcavacata di Rende)
10.20 Biotin-tagging of bilitranslocase in the intact liver as a mean for its detection and purification by avidin-biotin techniques.
R. Cecotti, S. Passamonti (University of Trieste)
10.40 Expression and function of bilitranslocase in vascular endothelial cells.
M. Terdoslavich, A.Maestro, A. Kuku, V. Nicolin, G. Decorti, S. Passamonti (University of Trieste)
11.00- 11.20 COFFEE BREAK
INTEGRATED CELLULAR FUNCTIONS
Chairman: Nazzareno Capitanio (University of Foggia)
11.20 cAMP-dependent protein kinase and A-kinase anchor proteins in the inner compartment of mammalian heart mitochondria
A. Signorile, A.M. Sardanelli, R. Nuzzi, D.De Rasmo, Z. Technikova-Dobrova, Z. Drahota, A.Pica, A. Occhiello, S. Papa
11.40 The energetic failure caused by severe mutations in the mitochondrial genome is not rescued by Bcl-2 overexpression
M. Hoque, A.M. Porcelli, A. Ghelli, L. Iommarini, M. Rugolo (University of Bologna)
12.00 NASH induces expression of UCP2 and mitochondria respiratory impairment in liver hepatocytes
G. Serviddio, R.Tamborra, F.Bellanti, T.Rollo, A. Romano, E.Altomare, G.Vendemiale (University of Foggia)
12.20 Role of calcium in mitochondrial dysfunctions induced by hepatitis C virus infection.
C. Piccoli, R. Scrima, A. D’Aprile, G. Quarato, M. Ripoli, L. Lecce, D. Boffoli, D. Moradpour, N. Capitanio (University of Foggia)
12.40 Species-specific stimulation of the mitochondrial permeability transition by norbormide analogues.
A. Zulian, V. Petronilli, P. Bernardi, S. Bova, F. Dabbeni-Sala, G. Cargnelli, M. Cavalli, F. Ricchelli (University of Padova)
In allegato (PDF) libro degli abstracts