Second International GIBB Meeting

Programme

Thursday 13th June

13:00 - 15.00 Registration
15:00 - 15.30 Welcoming address Authorities, GIBB President and the Organizing Committee

Opening Plenary Lecture
Chair: Alessandro Giuffr egrave; (CNR Rome, Italy)
15:30 - 16.15 Barbara Schoepp-Cothenet (BIP Laboratory, UM7281 AMU/CNRS, Marseille, France)
Using phylogenetics in studying bioenergetic metalloenzymes: the case of enzymes working in arsenic metabolism

Session I. Respiratory Chain Complexes, ATP Synthase, Redox Biology
Chairs: Alessandro Giuffrè (CNR, Rome), Francesco Francia (University of Bologna)

16.15 - 16.30 Chiara Galber (University of Padova)
Role of F-ATP synthase f subunit in dimer formation and PTP modulation
16.30 - 16.45 Carolina Hierro Yap (University of South Bohemia)
The mitochondrion of Trypanosoma brucei’s infectious stage: how minimalism can broaden your limits
16.45 - 17.00 Leonid A. Ivontsin (Institute of Cytochemistry and Molecular Pharmacology, Moscow)
Proton transport through the inlet half-channel of F0F1-ATP synthase: new insights and perspective
17.00 - 17.15 Luigi Leonardo Palese (University of Bari)
What about the structures of the cytochrome c oxidase tell us about the mechanism
17.15 - 17.30 Piero Leone (University of Bari)
FAD forming and destroying via human FAD synthase: a puzzle of modulated and modulating activities
17.30 - 17.45 Francesco Bellanti (University of Foggia)
Defective transdifferentiation of senescent hepatic progenitor-like cells is associated with impairment of mitochondrial bioenergetics

18.00 - 19.00 Welcome cocktail

20.00 - 22.00 Guided tour to Vieste

Friday 14th June

Opening Plenary Lecture
Chair: Nazzareno Capitanio (University of Foggia)
08.45 - 09.30 Yaarit Adamovich (University of Tel Aviv)
Using The Interplay Between Oxygen and Circadian Clocks

Session II. Bioenergetics Metabolism and Mitochondrial (Dys)Function I
Chairs: Paolo Bernardi (University of Padova), Annamaria Tonazzi (CNR, Bari)

09.30 - 09.45 Giuseppe Cannino (University of Padova)
TRAP1 regulation in cancer metabolism: identification of new interactors
09.45 - 10.00 Consiglia Pacelli (University of Foggia)
Parkin mutation affects the clock genes-dependent energy metabolism
10.00 - 10.15 Francesca Liuzzi (University of Bologna)
IF₁ promotes cancer cells survival under anoxic conditions
10.15 - 10.30 Claudio Laquatra (University of Padova)
Zebrafish (Danio rerio) as a model to study the pathophysiological role of the mitochondrial chaperone TRAP1
10.30 - 10.45 Pauline Dao (Medical University of Vienna)
Dissecting mitochondrial functions in brain, behavior and timing with the human disease gene LETM1

11.00 - 13.45 Tour on Boat to the Sea-Caves and Swim in the Sea

14.00 - 15.00 Lunch

Session II. Bioenergetics Metabolism and Mitochondrial (Dys)Function I (continued)

15.00 - 15.15 Karim Zuhra (CNR Institute of Molecular Biology and Pathology, Rome) N-acetylcysteine serves as substrate of 3-mercaptopyruvate sulfurtransferase and boosts sulfide metabolism in colon cancer cells
15.15 - 15.30 Francesca Agriesti
Nandrolone induces a stem cell-like phenotype inhibiting mitochondrial respiratory activity
15.30 - 15.45 Francesco Tucci (University of Foggia)
Cell metabolism profile of different embryonic stem cells

Session III. Transporters and Pores: Structure and Physio Pathology I
Chairs: Giovanna Lippe (Università di Udine), Vito de Pinto (Università di Catania)

15.45 - 16.00 Lara Console (University of Calabria)
Role of Tryptophan 224 in the transport mechanism of the mitochondrial carnitine/acylcarnitine carrier
16.00 - 16.15 Ruggero Gorgoglione (University of Bari)
Molecular identification and functional characterization of a novel glutamate transporter in yeast and plant mitochondria

16.15 - 16.45 Coffee break

16.45 - 17.00 Veronica Fiorito (University of Torino)
Metabolic adaptation in colorectal cancer: heme export is required for the down modulation the tricarboxylic acid cycle
17.00 - 17.15 Emma Aloe (University of Calabria)
Effect of cholesterol on the human ASCT2 amino acid transporter
17.15 - 17.30 Marco Schiavone (University of Padova)
A mitochondrial therapy for Duchenne muscular dystrophy
17.30 - 17.45 Anna Stocco (University of Padova)
Cyclophillins in Duchenne muscular dystrophy
17.45 - 18.00 Andrea Urbani (University of Padova)
Ca²⁺-dependent high-conductance channel activity of F-ATP synthase matches the permeability transition pore

18.00 GIBB member annual meeting

20.30 Social dinner

Saturday 15th June

Session III. Bioenergetics Metabolism and Mitochondrial (Dys)Function II
Chairs: Luigi Palmieri (University of Bari), Elena Forte (University of Roma, La Sapienza)

09.00 - 09.15 Silvia Russo (University of Bari)
Mitochondrial signature in human ovarian cancer tissue: involvement of cAMP pathway, SIRT3, OPA1 and PHB2 proteins
09.15 - 09.30 Vidyasagar Naik Bukke (University of Foggia)
Effect of obethicholic acid on liver mitochondria in a model of secondary biliary cirrhosis
09.30 - 09.45 Federica Taurino (University of Bari)
Proteomic-driven analysis reveals a dysregulation of a key mitochondrial protein in Short-Term Type-1 Diabetes Mellitus
09.45 - 10.00 Arcangela Iuso (Institute of Human Genetics, Helmholtz Zentrum Munich, Germany)
Development of treatment strategy for MPAN, a sub-type of Neurodegeneration with Brain Iron Accumulation (NBIA)
10.00 - 10.15 Anna Ferretta (University of Bari)
Increased levels of cAMP by the calcium-dependent activation of soluble adenylyl cyclase in parkin-mutant fibroblasts
10.15 - 10.30 Elisabetta Wyart (University of Torino)
Iron availability regulates cancer related skeletal muscle wasting

10.30 - 11.00 Coffee Break

Session IV. Transporters and Pores: Structure and Physio Pathology II
Chairs: Cesare Indiveri (University of Calabria), Marco Zancani (University of Udine)

11.00 - 11.15 Technical presentation
Enrico Tatti (Biolog, Hayward Inc. California, USA)
Biolog Mitoplates^TM: a novel tool to assess mitochondrial functions in eukaryotic cells
11.15 - 11.30 Mariafrancesca Scalise (University of Calabria)
The human SLC38A9 transceptor: insights into the transport side and structure/function relationship
11.30 - 11.45 Andrea Carrer (University of Padova)
Electrophysiological characterization of channel formed by F-ATP synthases
11.45 - 12.00 Rosaria Saletti (University of Catania)
Oxidation state of methionine and cysteine residues in human mitochondrial Voltage-Dependent Anion Selective Channel isoforms (hVDAC) investigated by high resolution mass spectrometry
12.00 - 12.15 Maria Tolomeo (University of Bari)
Function and dysfunction of human riboflavin transporters

12.15 - 12.45 Concluding remarks and awards

13.00 Lunch / lunch box

14.00 End of the meeting